Chemistry

Application of the tetraisopropyldisiloxane-1, 3-diyl group in the chemical synthesis of oligoribonucleotides

WT MARKIEWICZ, E BIAŁA, R KIERZEK

文献索引：Markiewicz, Wojciech T.; Biala, Ewa; Kierzek, Ryszard Bulletin of the Polish Academy of Sciences, Chemistry, 1984 , vol. 32, # 11-12 p. 433 - 451

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被引用次数: 46

摘要

Summary. The application of the tetraisopropyldisiloxane-K3-diyl (TIPDSi) group for the large-scale preparation of the key components for the chemical synthesis of oligoribonucleotides by the triester approach is described. The key components, N-benzol-2'- 0-tetrahydropyranyl-S'-O-dimethoxytritylnucleoside 3'(p-chlorophenyl, 2-cyanoethyl) phosphates for uridine, cytidine, adenosine and guanosine (1-4), respectively, are ...