Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase α

…, K Ikeda, M Takemura, H Yoshida, K Sakaguchi…

文献索引：Kuriyama, Isoko; Asano, Naoki; Kato, Ikuo; Ikeda, Kyoko; Takemura, Masaharu; Yoshida, Hiromi; Sakaguchi, Kengo; Mizushina, Yoshiyuki Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 2187 - 2196

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被引用次数: 21

摘要

We reported previously that a novel dipeptide alcohol, l-homoserylaminoethanol (Hse-Gly- ol), is a selective inhibitor of eukaryotic DNA polymerase ε (pol ε)[Bioorg. Med. Chem. 2004, 12, 957–962]. The discovery suggests that the dipeptide structure could be a chemical frame for a DNA polymerase inhibitor. Therefore, we chemically synthesized 27 different species of dipeptide alcohols, and tested this inhibitory capability. Compound 6 (l- ...