Journal of the American Chemical Society

Conformational and medium effects on intramolecular carbene reactions

RR Rando

文献索引：Rando,R.R. Journal of the American Chemical Society, 1972 , vol. 94, p. 1629 - 1631

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被引用次数: 25

摘要

Abstract: The photochemical decomposition of a-diazoamides leads to the intramolecular formation of lactams. Thus, the photolysis of N, N-diethyldiazoacetamide (1) in dioxane produces l-ethyl-4-methyl-2-azetidinone (2) and 1-ethyl-2-pyrollidinone (3) in roughly equal amounts. Striking solvent effects are observed on these reactions. As the polarity of the medium is increased, the ratio of@-lactamly-lactam increases. he gross effects of structure ...