Tetrahedron

Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

T Matsumaru, T Sunazuka, T Hirose, A Ishiyama…

文献索引：Matsumaru, Takanori; Sunazuka, Toshiaki; Hirose, Tomoyasu; Ishiyama, Aki; Namatame, Miyuki; Fukuda, Takashi; Tomoda, Hiroshi; Otoguro, Kazuhiko; Omura, Satoshi Tetrahedron, 2008 , vol. 64, # 30-31 p. 7369 - 7377

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被引用次数: 5

摘要

The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal SN2′ type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma ...