Design of PAP-1, a selective small molecule Kv1. 3 blocker, for the suppression of effector memory T cells in autoimmune diseases

A Schmitz, A Sankaranarayanan, P Azam…

文献索引：Molecular Pharmacology, , vol. 68, # 5 p. 1254 - 1270

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被引用次数: 138

摘要

... The first small molecules that were found to inhibit the Kv channel in human T cells ... companies started screening their libraries for more potent and more selective small molecule Kv1.3 ... Wulff et al., 2003a), which are of a relatively simple structure and low molecular weight and ...