Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle

…, H Yoshino, T Okauchi, K Yoshimatsu…

文献索引：Owa, Takashi; Yoshino, Hiroshi; Okauchi, Tatsuo; Yoshimatsu, Kentaro; Ozawa, Yoichi; Sugi, Naoko Hata; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3789 - 3799

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被引用次数: 227

摘要

Described herein is the discovery of a novel series of antitumor sulfonamides targeting G1 phase of the cell cycle. Cell cycle control in G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins involved in G1 progression or G1/S transition have been found to play a crucial role in proliferation, differentiation, transformation, and programmed cell death (apoptosis). We previously reported our first ...