5-tert-Butyl-N-pyrazol-4-yl-4, 5, 6, 7-tetrahydrobenzo [d] isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate …

S Velaparthi, M Brunsteiner, R Uddin…

文献索引：Velaparthi, Subash; Brunsteiner, Michael; Uddin, Reaz; Wan, Baojie; Franzblau, Scott G.; Petukhov, Pavel A. Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 1999 - 2002

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被引用次数: 90

摘要

Pantothenate synthetase (PS) is one of the potential new antimicrobial targets that may also be useful for the treatment of the nonreplicating persistent forms of Mycobacterium tuberculosis. In this Letter we present a series of 5-tert-butyl-N-pyrazol-4-yl-4, 5, 6, 7- tetrahydrobenzo [d] isoxazole-3-carboxamide derivatives as novel potent Mycobacterium tuberculosis PS inhibitors, their in silico molecular design, synthesis, and inhibitory activity.