Synthesis by microwave irradiation of a substituted benzoxazine parallel library with preferential relaxant activity for guinea pig trachealis

G Caliendo, E Perissutti, V Santagada, F Fiorino…

文献索引：Caliendo, Giuseppe; Perissutti, Elisa; Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Cirillo, Donatella; D'Emmanuele Di Villa Bianca, Roberta; Lippolis, Laura; Pinto, Aldo; Sorrentino, Raffaella European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 815 - 826

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被引用次数: 39

摘要

An efficient, facile, and practical parallel combinatorial synthesis of substituted- benzoxazines under microwave irradiation was described. The procedure involved the use of a microwave oven especially designed for organic synthesis suitable for parallel synthesis of solution libraries. A demonstration 19-membered library of substituted N, N-dimethyl-and N-methyl-benzoxazine amide derivatives, structurally related to the potassium channel ...