(S)-2-Amino-4-(2-pentadecyl-1, 3-dioxolan-2-yl)-butanoic acid, 11, Pdiob, a synthetic analogue C-isostere of palmitoylated cysteine, has been prepared starting from tetrabenzyl glutamic acid. The less hindered benzyl carboxylate ester was transformed into the corresponding β-ketophosphonate and subjected to a Horner–Wadsworth–Emmons reaction followed by hydrogenation/hydrogenolysis. This product was used for the ...
