Carbohydrate research

Thiosugar nucleotide analogs: Synthesis of 5′-(2, 3, 4-tri-O-acetyl-6-S-acetyl-6-thio-α-d-galactopyranosyl diphosphate)

J Elhalabi, KG Rice

文献索引：Elhalabi, Jordan; Rice, Kevin G. Carbohydrate Research, 2002 , vol. 337, # 21-23 p. 1935 - 1940

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被引用次数: 15

摘要

The synthesis of a novel analog of uridine diphosphate galactose (UDP-Gal) is described. A sulfur atom was inserted into the 6-position of galactose to give uridine 5′-(2, 3, 4-tri-O- acetyl-6-S-acetyl-6-thio-α-d-galactopyranosyl diphosphate). This peracetylated thiol analogue of UDP-Gal has been synthesized in nine steps starting from methyl α-d- galactopyranoside in an overall yield of 3%.