Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease

ZP Xiao, DH Shi, HQ Li, LN Zhang, C Xu…

文献索引：Xiao, Zhu-Ping; Shi, Da-Hua; Li, Huan-Qiu; Zhang, Li-Na; Xu, Chen; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3703 - 3710

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被引用次数: 101

摘要

Twenty polyphenols were synthesized and evaluated for their effect on Helicobacter pylori urease. Among these compounds, 4-(p-hydroxyphenethyl) pyrogallol (15)(IC50= 0.03 mM) and 7, 8, 4′-trihydroxyisoflavone (19)(IC50= 0.14 mM) showed potent inhibitory activities, and inhibited Helicobacter pylori urease in a time-dependent manner. The structure–activity relationship of these polyphenols revealed: the two ortho hydroxyl groups were essential ...