Synlett

One-pot Van Leusen synthesis of 4, 5-disubstituted oxazoles in ionic liquids

B Wu, J Wen, J Zhang, J Li, YZ Xiang, XQ Yu

文献索引：Wu, Bo; Wen, Jun; Zhang, Ji; Li, Jing; Xiang, Yong-Zhe; Yu, Xiao-Qi Synlett, 2009 , # 3 p. 500 - 504

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被引用次数: 21

摘要

Abstract An efficient and mild protocol for the preparation of 4, 5-disubstituted oxazoles through an improved one-pot van Leusen oxazole synthesis in ionic liquids is described. The oxazole products were prepared from tosylmethyl isocyanide (TosMIC), aliphatic halides and various aldehydes in high yields. The recovered ionic liquids could be reused as solvent for six runs without significant loss of yields.