Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4

J Zhou, J Jin, Y Zhang, Y Yin, X Chen, B Xu

文献索引：Zhou, Jie; Jin, Jing; Zhang, Yi; Yin, Yuwen; Chen, Xiaoguang; Xu, Bailing European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 222 - 232

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被引用次数: 15

摘要

Abstract A series of novel oxazole-bridged analogs of combretastatin A-4 bearing a benzo [d]-imidazole as B ring were synthesized and evaluated for antiproliferative activities against five human cancer cell lines. Among all the synthesized compounds, the N-unsubstituted benzoimidazole analog 5 and the analogs 6b, 7a and 7b with a small hydrophobic group on nitrogen atom of benzoimidazole ring were identified as the most potent inhibitors of tumor ...