Synthesis of the non-K-region and K-region trans-dihydrodiols of benzo [e] pyrene

RE Lehr, CW Taylor, S Kumar, HD Mah…

文献索引：Lehr; Taylor; Kumar; et al. Journal of Organic Chemistry, 1978 , vol. 43, # 18 p. 3462 - 3466

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被引用次数: 25

摘要

Syntheses of trans-9, 10-dihydroxy-9, lO-dihydrobenzo [e] pyrene (14b) and of trans-4, 5- dihydroxy-4, 5-dihydro-benzo [e] pyrene (17a) are described. The preparation of the non-K- region trans-dihydrodiol 14b proceeded via standard procedures from 9-oxo-9, 10, 11, 12- tetrahydrobenzo [e] pyrene (7), the synthesis of which is described. Intramolecular cyclization of methyl 4-pyrenylbutyrate (6) in HF produced primarily the undesired seven- ...