Tetrahedron Letters

Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5′-hydroxyl protecting group: toward oligonucleotide synthesis without acid …

K Seio, M Sekine

文献索引：Seio, Kohji; Sekine, Mitsuo Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8657 - 8660

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被引用次数: 16

摘要

Several alkyl- or arylthio groups have been used for sulfenamide-type protection of various amino compounds. 1., , and In particular, protection of nucleic acid bases by the tritylthio (TrS) 2., , and group has been studied widely because it can be removed by treatment with mild neutral reagents such as tributyltin hydride 2a and iodine. and Although the property of the TrS group as an amino protecting group has been well studied, little is known about this protecting group as a ...