Synthetic communications

Cost-effective and Large-scale synthesis of 16: 0 Lysophosphatidic Acid

JE East, TL Macdonald

文献索引：East, James E.; MacDonald, Timothy L. Synthetic Communications, 2012 , vol. 42, # 24 p. 3614 - 3619

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摘要

Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention because of its role in neoplastic diseases. Popularity of the compound has necessitated the use of large quantities of the phospholipid for in vivo and in vitro testing, but methods for generating LPA require the use of costly procedures, namely phosphoramidite coupling reagents. Additionally there has been no reported large-scale synthesis of LPA. In the present study we report the cost- ...