Chemistry and physics of lipids

An expeditious synthesis of 4-hydroxy-2 (E)-nonenal (4-HNE), its dimethyl acetal and of related compounds

L Soulere, Y Queneau, A Doutheau

文献索引：Soulere, Laurent; Queneau, Yves; Doutheau, Alain Chemistry and Physics of Lipids, 2007 , vol. 150, # 2 p. 239 - 243

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被引用次数: 22

摘要

The facile one step synthesis of 4-hydroxy-2 (E)-nonenal and its dimethyl acetal via a cross- metathesis reaction between commercially available octen-3-ol and acrolein or its dimethyl acetal is reported. The method was extended to the synthesis of C6 and C12 4-hydroxy-2 (E)- enals, their dimethyl acetal and of the 4-hydroxy-2 (E)-nonenoic acid (4-HNA).