Bioorganic & medicinal chemistry letters

Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure

T Fichert, A Regelin, U Massing

文献索引：Fichert, Thomas; Regelin, Anne; Massing, Ulrich Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 787 - 791

全文：HTML全文

被引用次数: 35

摘要

This report describes the synthesis and the transfection properties of novel monocationic non-toxic lipids. We have carried out structural variations in all three units of the transfection lipid, the lipid anchor, the spacer moiety and the positively charged head group. Our results lead to the conclusion that systematic modification of structural subunits is a promising way to enhance the transfection efficiency.