Cyclic ADP-Ribose via Stereoselective Cyclization of. beta.-NAD

S Yamada, QM Gu, CJ Sih

文献索引：Yamada, Shinji; Gu, Qu-Ming; Sih, Charles J. Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10787 - 10788

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被引用次数: 25

摘要

Cyclic ADP-ribose (cADPR) is a naturally occurring cyclic nucleotide and a potent mediator of calcium mobilization in many mammalian tissues.'Recent studies suggest that cADPR may play an important role as a second messenger, analogous to inositol triphosphate (IP# in Ca2+ signaling, but targeting a different intracellular Ca2+ channel, the ryanodine re~ eptor.~ cADPR is a metabolite of/?-NAD+, and its synthesizing enzyme,/?-NAD+ cyclase, ...