Efficient One??Step Synthesis of Bis??Spiroketals from Diynediols by π??Lewis Acid??Catalyzed Hydroalkoxylation/Hydration

I Volchkov, K Sharma, EJ Cho…

文献索引：Volchkov, Ivan; Sharma, Kamlesh; Cho, Eun Jin; Lee, Daesung Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 1961 - 1966

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被引用次数: 13

摘要

Tricyclic bis-spiroketal ring systems [1] are found in a wide range of biologically active natural products such as spirolides,[2] pinnatoxins and pteriatoxins,[3] spirastrellolides,[4] and the azaspiracids.[5] Compared to numerous syntheses of the simpler bicyclic spiroketal, a more common ketal scaffold indigenous to polyketide-based natural products,[6] there are only a limited number of the tricyclic bis-spiroketal syntheses and their synthetic methods. ...