The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

KA Roper, MB Berry, SV Ley

文献索引：Roper, Kimberley A.; Berry, Malcolm B.; Ley, Steven V. Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1781 - 1790

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被引用次数: 7

摘要

Abstract The application of a monolithic form of triphenylphosphine to the Ramirez gem- dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem- dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purification. It is also possible to perform the Appel reaction using the same monolith and the relationship between the mechanisms of the two ...