Tetrahedron letters

Proline 4-hydroxylase: stereochemical course of the reaction

…, RA Field, CC Lawrence, KD Merritt, CJ Schofield

文献索引：Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J. Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492

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被引用次数: 25

摘要

Abstract The stereochemical course of the hydroxylation of (S)-proline by proline 4- hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4- 2 H 1]-proline and (2S, 4R)-[4-2 H 1]-proline and found to occur with retention of stereochemistry at C-4 of proline.