Advanced Synthesis & Catalysis

New Synthetic Strategy for High??Enantiopurity N??Protected α??Amino Ketones and their Derivatives by Asymmetric Hydrogenation

T Sun, G Hou, M Ma, X Zhang

文献索引：Sun, Tian; Hou, Guohua; Ma, Miaofeng; Zhang, Xumu Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 253 - 256

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被引用次数: 15

摘要

Abstract Asymmetric hydrogenation of α-dehydroamino ketones catalyzed by a rhodium- chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral α-amino ketones. The reduction of α-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.