A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

T Kitazume, M Asai, T Tsukamoto…

文献索引：Kitazume, Tomoya; Asai, Masatomo; Tsukamoto, Takashi; Yamazaki, Takashi Journal of Fluorine Chemistry, 1992 , vol. 56, # 3 p. 271 - 284

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被引用次数: 33

摘要

Abstract A synthetic approach to both enantiomers of the secondary alcohols [Ph (CH 2) n CH (OH) CXF 2 (n= 0− 2) C 6 H 13 (CH 2) n CH (OH) CFX 2 (n= 0 or 2) and CXF 2 CH (OH) CH 2 CO 2 Et [X= H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.