This molecule, which exhibits a pentasubstituted pyridine structure, was prepared from 2- chloropyridine in 13 steps, by metalating and then functionalizing, one after another, all the remaining positions of the pyridine ring. The methodology involves four metalation steps (including metalation of 2, 3-dimethoxypyridine and pyridyl Nfl-diisopropylcarbamates), one halogen-scrambling step, and one bromine-lithium exchange step.
