The Journal of Organic Chemistry

Fluorinated aromatic amino acids. 1, 2 II. 2-and 3-trifluoromethyltyrosines. hydrolytic stability of the trifluoromethyl group on the aromatic nucleus

R Filler, H Novar

文献索引：Filler,R.; Novar,H. Journal of Organic Chemistry, 1961 , vol. 26, p. 2707 - 2710

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被引用次数: 13

摘要

% Tnfluorometh3. l-Dzs~ e (I) was prepared in 17% yield by the reaction of 2-tdluommethyl4- hydmxy benxenedt aaonium chloride with acrylic acid (Meenvein reaction), followed by ammonolysis. Attempts to prepare I via the &tone route failed. BT~ uoromethyl-nL-tyrosine (11) could not be prepared by either of these pathways, dthough3-tritiuoromethyl-4methoxy- ~~-pheny&nhe waa obtained in impure form by the Meemein route. The critical factor in ...