N-Aryl-N′-(chroman-4-yl) ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of …

…, D Lamoral-Theys, N Tajeddine, P De Tullio…

文献索引：Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844

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被引用次数: 9

摘要

A series of chroman derivatives previously reported as potassium channel openers, as well as some newly synthesized simplified structures, were examined for their in vitro effects on the growth of three human high-grade glioma cell lines: U373, T98G, and Hs683. Significant in vitro growth inhibitory activity was observed with 2, 2-dimethylchroman-type nitro- substituted phenylthioureas, such as compounds 4o and 4p. Interestingly, most tested ...