A total synthesis of (−)-antimycin A 3b

T Tsunoda, T Nishii, M Yoshizuka, C Yamasaki…

文献索引：Tsunoda; Nishii; Yoshizuka; Yamasaki; Suzuki; Ito Tetrahedron Letters, 2000 , vol. 41, # 40 p. 7667 - 7671

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被引用次数: 43

摘要

Although the structure of antimycin A 3 had been established as 3-methylbutanoate (+)-1 with a unique nine-membered dilactone structure, recent analytical investigations using HPLC disclosed that antimycin A 3 was in fact a mixture of (+)-1, now renamed antimycin A 3b , and its acyloxy isomer at the 8-position, which is 2-methylbutanoate, named antimycin A 3a . 3 b, 4 Since the separation of A 3a and A 3b is possible only with enormous effort, pure material of each ...