2-Trifluoroacetyl aminoindoles as useful intermediates for the preparation of 2-acylamino indoles

…, X Chen, R Krishnamoorthy, AS Vellekoop, AJ Csakai…

文献索引：Mangette, John E.; Chen, Xuemei; Krishnamoorthy, Ravi; Samuel Vellekoop; Csakai, Adam J.; Camara, Fatoumata; Paquette, William D.; Wang, Hong-Jun; Takahashi, Hidenori; Fleck, Roman; Roth, Gregory P. Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1292 - 1295

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被引用次数: 7

摘要

A three-step method was developed to convert N-1 unprotected 3-substituted indoles to 3- substituted 2-acylaminoindoles. Established indole chlorination chemistry was employed to generate stable 2-trifluoroacetylamino indoles, which were subsequently deprotected and selectively acylated.