Design, synthesis, and pharmacological evaluation of ultrashort-to long-acting opioid analgesics
PL Feldman, MK James, MF Brackeen…
文献索引：Feldman, Paul L.; James, Michael K.; Brackeen, Marcus F.; Bilotta, Joanne M.; Schuster, Suzanne V.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2202 - 2208
In an effort to discover a potent ultrashort-acting p opioid analgetic that is capable of metabolizing to an inactive species independent of hepatic function, several classes of Canilidopiperidine analgetics were synthesized and evaluated. One series of compounds displayed potent p opioid agonist activity with a high degree of analgesic efficacy and an ultrashort to long duration of action. These analgetics, 4-(methoxycarbonyl)-4-[(l-oxopropyl ...
