Palladium??Catalyzed Decarboxylative Coupling of α??Oxocarboxylic Acids with C (sp2) H of 2??Aryloxypyridines

…, R Feng, Z Wu, Z Liu, Y Zhang

文献索引：Yao, Jinzhong; Feng, Ruokun; Wu, Zaihong; Liu, Zhanxiang; Zhang, Yuhong Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1517 - 1522

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被引用次数: 48

摘要

Abstract An efficient palladium-catalyzed decarboxylative ortho-acylation of 2- aryloxypyridines with α-oxocarboxylic acids is described. In this new transformation, the aromatic C (sp 2)[BOND] H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2-hydroxy aromatic ketones.