Synthetic studies of bacitracin. IX. Synthesis of peptide fragments for bacitracins of cycloheptapeptide formula

E Munekata, T Shiba, T Kaneko

文献索引：Munekata; Shiba; Kaneko Bulletin of the Chemical Society of Japan, 1973 , vol. 46, # 12 p. 3835 - 3839

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被引用次数: 4

摘要

In the synthetic study of bacitracins, peptide fragments corresponding to a branched part of bacitracin F, ie,(S)-2-(2-methylbutyryl) thiazole-4-carboxylic acid 1-succinimidyl ester (III) and L-leucyl-γ-t-butyl-D-glutamyl-L-isoleucine (IV), were prepared. As a macrocyclic part of bacitracin A and F of cycloheptapeptide formula, cyclo-(N α-benzyloxycarbonyl-L-lysyl-N δ- cyclopentyloxycarbonyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-β-benzyl-D- ...