A heterodimeric glucuronide prodrug for cancer tritherapy: the double role of the chemical amplifier

M Grinda, J Clarhaut, I Tranoy??Opalinski…

文献索引：ChemMedChem, , vol. 6, # 12 p. 2137 - 2141

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被引用次数: 13

摘要

... ChemMedChem, 6: 2137–2141. ... Volume: Issue: Page: ... Indeed, the optimal pH for β-glucuronidase activity is around 4, whereas the pH of tumor extracellular media is 6–7. In this context, the use of novel targeting devices such as 1 should circumvent this problem through the ...