Syntheses of (+)-asperlin 1 were achieved via two different synthetic routes. 1, 2-Addition of α-furyl anion to (2R, 3S)-2-tbutyldimethylsilyloxy-3-chlorobutanal 6 gave (1S, 2R, 3S)-1-(2- furyl)-2-tbutyldimethylsilyloxy-3-chlorobutanol 7, which was converted to the chiral intermediate,(1S, 2R, 3R)-1-(2-furyl)-2, 3-epoxybutanol 8 (37% overall yield from 6) for the synthesis of (+)-1. The second synthesis of (+)-asperlin 1 from (2R, 3S)-6 was achieved in ...
