A modular approach for ligand design for asymmetric allylic alkylations via enantioselective palladium-catalyzed ionizations

BM Trost, DL Van Vranken, C Bingel

文献索引：Trost, Barry M.; Van Vranken, David L.; Bingel, Carsten Journal of the American Chemical Society, 1992 , vol. 114, # 24 p. 9327 - 9343

全文：HTML全文

被引用次数: 514

摘要

Abstract: A new class of ligands for asymmetric transition metal catalysis based on 2- (dipheny1phosphino) benzoic acid was used in a mechanisticallydefmed palladium- catalyzed reaction in which enanticdiierentiation was the result of selective ionization of substrates derived from cis-2tycloallcene-l, 4-diols. By making rational, stepwise changes in the ligand structure, the structural requirements for good asymmetric induction were ...