A Comparative Repair Study of Thymine??and Uracil??Photodimers with Model Compounds and a Photolyase Repair Enzyme
J Butenandt, R Epple, EU Wallenborn…
文献索引：Butenandt, Jens; Epple, Robert; Wallenborn, Ernst-Udo; Eker, Andre P. M.; Gramlich, Volker; Carell, Thomas Chemistry - A European Journal, 2000 , vol. 6, # 1 p. 62 - 72
Abstract Cyclobutane uridine and thymidine dimers with cis-syn-structure are DNA lesions, which are efficiently repaired in many species by DNA photolyases. The essential step of the repair reaction is a light driven electron transfer from a reduced FAD cofactor (FADH−) to the dimer lesion, which splits spontaneously into the monomers. Repair studies with UV-light damaged DNA revealed significant rate differences for the various dimer lesions. In ...
