Bioorganic & medicinal chemistry

Metabolism of the phytoalexins camalexins, their bioisosteres and analogues in the plant pathogenic fungus Alternaria brassicicola

MSC Pedras, A Abdoli

文献索引：Pedras, M. Soledade C.; Abdoli, Abbas Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4541 - 4549

全文：HTML全文

被引用次数: 8

摘要

The metabolism of the phytoalexins camalexin (1), 1-methylcamalexin (10) and 6- methoxycamalexin (11) by Alternaria brassicicola and their antifungal activity is reported. This work establishes that camalexins are slowly biotransformed (ca. six days) to the corresponding indole-3-thiocarboxamides, which are further transformed to the indole-3- carboxylic acids. These metabolites are substantially less inhibitory to A. brassicicola than ...