Abstract Modified syntheses of the title compounds used the enhanced reactivity of the aromatic fluorine atom in exchange reactions and proceeded via fluorinated intermediates. 2- (2-Fluorophenylthio)-5-(methylthio) nitrobenzene (III) was synthesized, reduced to the amine IV which was alkylated with 2-(2-chloroethyl)-1-methylpiperidine to compound VI. This was cyclized with sodium hydride in dimethyl sulfoxide to thioridazine (I) in excellent yield. The ...
