Tetrahedron letters

Reductive defluorination of polyfluoroarenes by zinc in aqueous ammonia

SS Laev, VD Shteingarts

文献索引：Laev, Sergey S.; Shteingarts, Vitalij D. Tetrahedron Letters, 1997 , vol. 38, # 21 p. 3765 - 3768

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被引用次数: 28

摘要

Aqueous ammonia has been found to be a good and versatile medium for the reductive defluorination of polyfluoroarenes by zinc. Upon the reduction of pentafluorobenzoic acid, 2, 3, 4, 5, 6-pentafluorobenzyl alcohol, pentafluoropyridine and heptafluoro-2-naphthoic acid individual products derived from the removal of one fluorine atom have been obtained.