European Journal of Organic Chemistry

Chemoenzymatic Asymmetric Total Synthesis of Nonanolide (Z)??Cytospolides D, E and Their Stereoisomers

RK Rej, S Nanda

文献索引：Rej, Rohan Kalyan; Nanda, Samik European Journal of Organic Chemistry, 2014 , vol. 2014, # 4 p. 860 - 871

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被引用次数: 7

摘要

Abstract Chemoenzymatic asymmetric total synthesis of the (Z)-isomer of the naturally occurring decanolide cytospolides D, E and six stereoisomers is reported. The main highlight of the synthetic venture involves ring-closing metathesis (RCM) reaction of a suitably functionalized ester compound, which was assembled by the Yamaguchi coupling of the required acid and alcohol fragments. The alcohol fragment was accessed by two ...