Hydrophilic residues at position 3 highlight unforeseen features of the fMLP receptor pocket

S Spisani, M Turchetti, K Varani, S Falzarano…

文献索引：Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19

全文：HTML全文

被引用次数: 11

摘要

The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met- Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, superoxide anion production, lysozyme release and receptor binding. Our results highlight that for-Met-Leu-Asp-OMe acts as a full ...