Molecules

Synthesis and cytotoxicity of novel 10-substituted dihydroartemisinin derivatives containing N-arylphenyl-ethenesulfonamide groups

Y Liu, Z Liu, J Shi, H Chen, B Mi, P Li, P Gong

文献索引：Liu, Yajing; Liu, Zijian; Shi, Jiyue; Chen, Huimin; Mi, Bin; Li, Peng; Gong, Ping Molecules, 2013 , vol. 18, # 3 p. 2864 - 2877

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被引用次数: 1

摘要

Abstract: The manuscript describes the synthesis of 10-substituted dihydroartemisinin derivatives containing N-aryl phenylethenesulfonamide groups and their in vitro anti-tumor activities against the HT-29, MDA-MB-231, U87MG, H460, A549 and HL-60 cancer cell lines and the normal WI-38 cell line. Most tested compounds showed enhanced cytotoxic activities and good selectivity toward the MDA-MB-231, HT-29 and HL-60 cell lines, with ...