Tetrahedron

Stereoselective tandem Michael-intramolecular cyclization approach to functionalized pyrroloisoindolones

…, P Demare, HA Jiménez-Vázquez, Y Ramírez…

文献索引：Reyes, Adelfo; Regla, Ignacio; Fragoso, Mabel C.; Vallejo, Laura A.; Demare, Patricia; Jimenez-Vazquez, Hugo A.; Ramirez, Yara; Juaristi, Eusebio; Tamariz, Joaquin Tetrahedron, 1999 , vol. 55, # 37 p. 11187 - 11202

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被引用次数: 9

摘要

A stereoselective synthesis of pyrrolo [2, 1-a] isoindol-5-ones is described. The synthesis takes place through a tandem Michael addition-intramolecular cyclization, by the base- promoted condensation of methyl N-phthaloylalaninate with conjugate acceptors at low temperature. The desired products were obtained in good yields as single isomers in only one step. Presumably, the stereoselectivity of the cyclization step is kinetically controlled ...