Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2- …

RT Jacobs, PR Bernstein, LA Cronk…

文献索引：Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297

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被引用次数: 22

摘要

Since their discovery in 1979, the peptidoleukotrienes LTC4 (11, LTD4 (21, and LTE4 (3) have been the subject of intense exploration. This interest lies in the fact that the leukotrienes (LTs) are potent constrictors of smooth muscle and, as such, have been ...