Synthesis and application of carbohydrate-derived morpholine amino acids
…, GA van der Marel, HS Overkleeft…
文献索引：Grotenbreg, Gijsbert M.; Tuin, Adriaan W.; Witte, Martin D.; Leeuwenburgh, Michiel A.; Van Boom, Jacques H.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.; Overhand, Mark Synlett, 2004 , # 5 p. 904 - 906
The synthesis of series of diversely functionalized ε-morpholine amino acids (MAAs, 5a-h) starting from an ε-sugar amino acid and following a two-step oxidative glycol cleavage/reductive amination strategy, is described. In an alternative synthetic scheme, diastereoisomerically pure δ-MAAs (12a, b) were obtained. Oligopeptides containing MAAs were prepared either by direct incorporation of a MAA building block or by subjecting a ...
