Nature Chemistry

Probing chemical space with alkaloid-inspired libraries

…, G Singh, JN Plampin III, D Rane, JL Wang, VW Day…

文献索引：McLeod, Michael C.; Singh, Gurpreet; Plampin, James N.; Rane, Digamber; Wang, Jenna L.; Day, Victor W.; Aube, Jeffrey Nature Chemistry, 2014 , vol. 6, # 2 p. 133 - 140

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被引用次数: 27

摘要

Screening of small-molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries because of their structural complexity and sp 3-rich character. Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally ...