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Practical asymmetric synthesis of a non-peptidic αvβ3 antagonist

SP Keen, CJ Cowden, BC Bishop…

文献索引:Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884

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被引用次数: 36

摘要

... Volume: Page: Digital Object Identifier (DOI). ... 30,31 We were, therefore, gratified to find that a Pd(OAc) 2 /dppf-catalyzed reaction of chloride 20 with borane 22 cleanly afforded the desired acetal 23 in near quantitative yield (98% after chromatography). ...