New approaches to the industrial synthesis of HIV protease inhibitors

Y Honda, S Katayama, M Kojima, T Suzuki…

文献索引：Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070

全文：HTML全文

被引用次数: 35

摘要

Efficient and industrially applicable synthetic processes for precursors of HIV protease inhibitors (Amprenavir, Fosamprenavir) are described. These involve a novel and economical method for the preparation of a key intermediate,(3S)-hydroxytetrahydrofuran, from L-malic acid. Three new approaches to the assembly of Amprenavir are also discussed. Of these, a synthetic route in which an (S)-tetrahydrofuranyloxy carbonyl is attached to L- ...

137515-66-3

(2R,3S)-1,2-环氧-...

Highly diastereoselective catalytic meerwein-ponndorf-verley...

[Yin, Jingjun; Huffman, Mark A.; Conrad, Karen M.; Armstrong III, Joseph D. Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 840 - 843]

Amino Diol HIV Protease Inhibitors. 1. Design, Synthesis, an...

[Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768]

Stereocontrolled Synthesis of Erythro N-Protected α-Amino Ep...

[Albeck, Amnon; Persky, Rachel Tetrahedron, 1994 , vol. 50, # 21 p. 6333 - 6346]

Design, Biologic Evaluation, and SAR of Novel Pseudo??peptid...

[He, Meizi; Zhang, Hang; Yao, Xiaojian; Eckart, Michael; Zuo, Elizabeth; Yang, Ming Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 174 - 180]