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Chemistry of emeriamine and its analogs and their inhibitory activity in long-chain fatty acid oxidation

S Shinagawa, T Kanamaru, S Harada…

文献索引:Shinagawa, Susumu; Kanamaru, Tsuneo; Harada, Setsuo; Asai, Mitsuko; Okazaki, Hisayoshi Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1458 - 1463

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被引用次数: 5

摘要

Emericedins A, B, and C, new betaines having inhibitory activity of long chain fatty acid oxidation, were isolated from the culture broth of Emericella quadrilineata IF0 5859. Their structures were determined by spectroscopic analyses as (R)-3-(acylamino)-4- (trimethylammonio) butyrate (acyl: A, acetyl; B, propionyl; C, n-butyryl). Structural confvmation and assignment of absolute configuration were made by chemical synthesis ...