Efficient Manganese/Copper Bimetallic Catalyst for N??Arylation of Amides and Sulfonamides Under Mild Conditions in Water

YC Teo, FF Yong, IK Ithnin, SHT Yio…

文献索引：Teo, Yong-Chua; Yong, Fui-Fong; Ithnin, Idzham Khalid; Yio, Siew-Hui Trionna; Lin, Zhiyin European Journal of Organic Chemistry, 2013 , # 3 p. 515 - 524

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被引用次数: 1

摘要

Abstract An efficient and mild method using a bimetallic MnF 2/CuI catalyst at 60 C in water was developed for the N-arylation of amides and sulfonamides with aryl halides. A variety of functionalized amides and sulfonamides were coupled with different substituted aryl halides to afford the corresponding N-arylated products in good to excellent yields (up to 97%).

~88%

~89%

~81%

~77%

~77%

~47%

~74%

~87%

~99%

~59%

~74%

~94%

~73%

~78%

~82%

~76%

~89%

~49%

~39%

~29%

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